Dr. Lee’s research focuses on molecular and cellular mechanisms of disease in arthritis [e.g., rheumatoid arthritis (RA) and osteoarthritis (OA)]. In complex diseases like RA and OA, it is now clear that disease pathogenesis does not result from a single genetic defect or environmental insult. Rather, disease pathogenesis results from interactions between multiple cellular lineages and incorporates numerous autoimmune and inflammatory molecular pathways. Thus, the Lee lab research projects incorporate studies of diverse cellular lineages and a number of molecular pathways. In these disease-focused studies, the Lee laboratory examines human biospecimens as well as in vivo and in vitro modeling systems. By using this combination of approaches, we hope to gain new insights into human disease mechanisms with an eye toward new, more effective treatments for this common disease.
Areas of Research
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Mast Cells and Inflammatory Arthritis
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Cadherin-11
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Molecular regulation of synovial mesenchymal tissue via cadherin-11
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